Sildenafil vs. tadalafil: a 3,200-word breakdown of how they actually differ
Onset, duration, side effect profile, interactions, and when each makes more sense. No marketing language.
The Science · Issue 012
The quiet epidemic of erectile dysfunction in men under 40 — and what the research actually says.
One in four men diagnosed with ED today is under forty. We spent four months with researchers, urologists, and patients to understand why — and what treatments actually work.
This week
All articles →
What morning wood actually tells you about your cardiovascular health
Nocturnal erections are one of the best quiet biomarkers we have. Here's what's happening at the tissue level.
I was thirty-one the first time it didn't work. A year of trying to understand why.
An anonymous first-person account of what the statistics don't capture — and what the medical system missed.
The Science
More research →
The nitric oxide pathway, explained — without hand-waving
For years we've been told an erection is mostly about blood flow. That's true, but it's the short answer. Here's the long one, from endothelium to orgasm.
Ask the Doctor
Submit a question →Q · Marco, 34, Chicago
"Why do I get morning wood, but lose it during sex?"
Dr. Pace: Morning erections are neurovascular — mostly parasympathetic and unconscious. Sex introduces performance anxiety, which is sympathetic. You have a wiring problem, not a plumbing problem…
Full answer →Q · J, 29, Austin
"I'm 29 and on 5mg daily tadalafil. Is this going to mess me up long-term?"
Dr. Pace: The ten-year data is actually reassuring. The more useful question is why you started in the first place — because that's often where the real signal is…
Full answer →Q · David, 41, Brooklyn
"Can I take a PDE5 inhibitor recreationally, even though I don't have ED?"
Dr. Pace: You can, and a lot of men do. Here's the honest, non-judgmental breakdown of what happens, what the risk looks like, and when it stops being worth it…
Full answer →Q · Anonymous, 38
"My doctor just shrugged. What tests should I actually be asking for?"
Dr. Pace: Here's the exact panel I'd run on a 38-year-old presenting with new ED — and the three that insurance will cover without a fight…
Full answer →Training, Sleep & Recovery
All lifestyle →
A four-week pelvic floor protocol, from a pelvic floor PT
The Mediterranean diet has the best ED evidence. It's not close.
Every extra hour of sleep raises morning testosterone by ~15%. The lab evidence.
Performance anxiety loops, and the CBT protocol urologists quietly recommend
The Comparison Desk
All guides →Every PDE5 inhibitor, compared on the seven things that actually matter.
Onset. Duration. Half-life. Food interaction. Alcohol interaction. Flush risk. Cost with no insurance. Here's the full table, built from prescribing information and clinical data.
Read the guide →The Healthy Fitness Goal Briefing
A weekly dispatch on the science of feeling like yourself.
One essay, three research links, and one practical thing to try this week. 42,000 readers. No spam.